Connectivity Map. Global network connection. World map point and line composition concept Lamb et al.' (1) is biased in favor of establishing the usefulness of a connectivity map for revealing connections among small molecules, genes, and diseases by generating gene-expression. But this remains a daunting task, and even the most inspired researchers still have to resort to laborious screens of genetic or chemical libraries.
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We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression signatures The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
Global Network Connection. World Map Point and Line Composition Concept
Here, we report more than a 1,000-fold scale-up of the CMap as part of the NIH LINCS Consortium, made possible by a new, low-cost, high-throughput reduced representation. Here, we report more than a 1,000-fold scale-up of the CMap as part of the NIH LINCS Consortium, made possible by a new, low-cost, high-throughput reduced representation. To build a Connectivity Map, the Broad brings together molecular biologists, genomics specialists, computational scientists, pharmacologists, chemists and chemical biologists, as well as expertise from across the breadth and depth of.
Global Digital Connectivity Map Illuminated Network Data Points Stock. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs The second challenge in the 2016 Connectivity Map series asked competitors to speed up the existing algorithm.
LINCS. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project. The Connectivity Map is a collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules and simple pattern-matching algorithms that together enable the discovery of decisive functional connections between drugs, genes, and diseases